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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-6-25
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pubmed:abstractText |
Non-viral vector-mediated targeted gene repair could become a useful alternative to classical gene addition strategies. The methodology guarantees a physiologically regulated and persistent expression of the repaired gene, with reported gene conversion and phenotypic correction efficiencies approaching 40-50% in some in vitro and in vivo models of disease. This is particularly important for cystic fibrosis (CF) because of its complex pathophysiology and the cellular heterogeneity of the cystic fibrosis transmembrane conductance regulator (CFTR) gene expression and function in the lung.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
625-39
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12825202-Base Sequence,
pubmed-meshheading:12825202-Bronchi,
pubmed-meshheading:12825202-Cell-Free System,
pubmed-meshheading:12825202-Cystic Fibrosis,
pubmed-meshheading:12825202-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:12825202-DNA Repair,
pubmed-meshheading:12825202-Epithelial Cells,
pubmed-meshheading:12825202-Gene Expression,
pubmed-meshheading:12825202-Gene Targeting,
pubmed-meshheading:12825202-Gene Therapy,
pubmed-meshheading:12825202-Humans,
pubmed-meshheading:12825202-Molecular Sequence Data,
pubmed-meshheading:12825202-Oligonucleotides,
pubmed-meshheading:12825202-Point Mutation,
pubmed-meshheading:12825202-Polymerase Chain Reaction,
pubmed-meshheading:12825202-Recombinant Fusion Proteins,
pubmed-meshheading:12825202-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Suitability of oligonucleotide-mediated cystic fibrosis gene repair in airway epithelial cells.
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pubmed:affiliation |
Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica, Hospital Duran i Reynals, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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