Source:http://linkedlifedata.com/resource/pubmed/id/12824721
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-6-25
|
| pubmed:abstractText |
Matrix metalloproteinase (MMP)-2 and MMP-9 are believed to play a pathophysiologic role in acute myocardial infarction (MI). The time course of their plasma concentrations in correlation with the extent of myocardial damage is unclear. In a prospective study, 20 patients with proven acute MI underwent successful reperfusion within 6 h after the onset of symptoms. The patients were divided into two groups according to the size of their MI, i.e. large or moderate MI. Plasma concentrations of MMP-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 were determined on admission, and after 24 h, 48 h, 1 week, 4 weeks, 3 months and 6 months. MMP-2 levels remained unchanged over time in both groups. The plasma concentration of MMP-9 was elevated on admission in patients with large MI versus moderate MI (195 +/- 190 versus 78 +/- 63 ng/ml, p < 0.01) as determined by left ventriculography, and returned to baseline (18 +/- 16 ng/ml) by 1 week after MI. TIMP-1 levels rose slowly in patients with large MI and returned to baseline at 6 months. The ratio of MMP-9 to TIMP-1 was significantly increased on admission in both groups and returned to baseline at 48 h. These data suggest that MMP-9 might play a pathophysiologic role during the early phase of acute MI.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0008-6312
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
|
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
140-4
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:12824721-Angioplasty, Balloon, Coronary,
pubmed-meshheading:12824721-Biological Markers,
pubmed-meshheading:12824721-Electrocardiography,
pubmed-meshheading:12824721-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12824721-Female,
pubmed-meshheading:12824721-Humans,
pubmed-meshheading:12824721-Male,
pubmed-meshheading:12824721-Matrix Metalloproteinase 2,
pubmed-meshheading:12824721-Matrix Metalloproteinase 9,
pubmed-meshheading:12824721-Middle Aged,
pubmed-meshheading:12824721-Myocardial Infarction,
pubmed-meshheading:12824721-Probability,
pubmed-meshheading:12824721-Prognosis,
pubmed-meshheading:12824721-Prospective Studies,
pubmed-meshheading:12824721-Sensitivity and Specificity,
pubmed-meshheading:12824721-Severity of Illness Index,
pubmed-meshheading:12824721-Time Factors,
pubmed-meshheading:12824721-Treatment Outcome
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Time-dependent changes in the plasma concentration of matrix metalloproteinase 9 after acute myocardial infarction.
|
| pubmed:affiliation |
1st Department of Medicine (Cardiology, Angiology and Pulmonology), University Hospital of Mannheim, Mannheim, Germany. jens.kaden@med.ma-uni-heidelberg.de
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|