Linked Life Data

12824477

Source:http://linkedlifedata.com/resource/pubmed/id/12824477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
188
pubmed:dateCreated
2003-6-25
pubmed:abstractText
Most neurotransmitter receptors belong to either the pentameric nicotinoid receptor family or the tetrameric glutamatergic receptor family. The muscle nicotinic acetylcholine receptor (AChR), the prototype of the nicotinoid receptor family, gates by switching between a closed configuration (in which ion permeation is forbidden) and an open configuration (which allows ions to pass through). Rate-equilibrium linear free energy relationship analysis has allowed us to explore the transition state that links these two stable conformations. A series of point mutations were made to individual AChR residues, and the ensuing changes in the rate constants of channel opening and closing for the fully liganded receptor were determined. These experiments suggest that gating occurs approximately as a reversible, solitary conformational wave that propagates between the neurotransmitter binding site and the membrane domain, along the long axis of the receptor. A detailed knowledge of the gating mechanism can serve as a basis for understanding the shape of the postsynaptic ion current and for the differences in synaptic responses among different ligand-gated channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1525-8882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
2003
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
re11
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Life at the top: the transition state of AChR gating.
pubmed:affiliation
Center for Single Molecule Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA. auerbach@buffalo.edu
pubmed:publicationType
Journal Article, Review