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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2003-6-25
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pubmed:abstractText |
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BartoliniAlessandroA,
pubmed-author:DeiSilviaS,
pubmed-author:GaleottiNicolettaN,
pubmed-author:GhelardiniCarlaC,
pubmed-author:GualtieriFulvioF,
pubmed-author:GuandaliniLucaL,
pubmed-author:ManettiDinaD,
pubmed-author:MartiniElisabettaE,
pubmed-author:RomanelliMaria NovellaMN,
pubmed-author:ScapecchiSerenaS,
pubmed-author:TeodoriElisabettaE
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2303-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12824022-Amnesia,
pubmed-meshheading:12824022-Animals,
pubmed-meshheading:12824022-Avoidance Learning,
pubmed-meshheading:12824022-Chemistry, Physical,
pubmed-meshheading:12824022-Cognition,
pubmed-meshheading:12824022-Dose-Response Relationship, Drug,
pubmed-meshheading:12824022-Indicators and Reagents,
pubmed-meshheading:12824022-Mice,
pubmed-meshheading:12824022-Muscarinic Antagonists,
pubmed-meshheading:12824022-Neurodegenerative Diseases,
pubmed-meshheading:12824022-Nootropic Agents,
pubmed-meshheading:12824022-Physicochemical Phenomena,
pubmed-meshheading:12824022-Piperidines,
pubmed-meshheading:12824022-Receptors, AMPA,
pubmed-meshheading:12824022-Scopolamine Hydrobromide,
pubmed-meshheading:12824022-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, I-50121, Firenze, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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