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pubmed-article:12824014pubmed:abstractTextThe synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.lld:pubmed
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pubmed-article:12824014pubmed:articleTitleNovel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.lld:pubmed
pubmed-article:12824014pubmed:affiliationLilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, IN, USA. engler_thomas@lilly.comlld:pubmed
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