Linked Life Data

12824014

Source:http://linkedlifedata.com/resource/pubmed/id/12824014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2003-6-25
pubmed:abstractText
The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/CDK4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Rubidium
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-894X
pubmed:author
pubmed-author:AndersonBryan DBD, pubmed-author:BrooksHarold BHB, pubmed-author:CampbellRobert MRM, pubmed-author:ConnerScottS, pubmed-author:ConsidineEileen LEL, pubmed-author:DeHahnTammy BTB, pubmed-author:DempseyJack AJA, pubmed-author:EnglerThomas ATA, pubmed-author:FaulMargaret MMM, pubmed-author:FurnessKellyK, pubmed-author:KirmaniKashifK, pubmed-author:KolisStanley PSP, pubmed-author:LytleMichelle LML, pubmed-author:MalhotraSushantS, pubmed-author:OggCatherine ACA, pubmed-author:PatelBharvinB, pubmed-author:Sanchez-MartinezConchaC, pubmed-author:SchultzRichard MRM, pubmed-author:ShihChuanC, pubmed-author:SpencerCharles DCD, pubmed-author:StammNancy BNB, pubmed-author:SullivanKevin AKA, pubmed-author:VasudevanVasuV, pubmed-author:WatkinsScott ASA, pubmed-author:XieWalterW, pubmed-author:ZhouXunX, pubmed-author:ZhuGuoxinG
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2261-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12824014-Antineoplastic Agents, pubmed-meshheading:12824014-Calcium-Calmodulin-Dependent Protein Kinase Type 2, pubmed-meshheading:12824014-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:12824014-Carbazoles, pubmed-meshheading:12824014-Cell Cycle, pubmed-meshheading:12824014-Cell Division, pubmed-meshheading:12824014-Cell Line, Tumor, pubmed-meshheading:12824014-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:12824014-Cyclin D1, pubmed-meshheading:12824014-Cyclin-Dependent Kinase 4, pubmed-meshheading:12824014-Cyclin-Dependent Kinases, pubmed-meshheading:12824014-Drug Screening Assays, Antitumor, pubmed-meshheading:12824014-Enzyme Inhibitors, pubmed-meshheading:12824014-Humans, pubmed-meshheading:12824014-Phosphorylation, pubmed-meshheading:12824014-Proto-Oncogene Proteins, pubmed-meshheading:12824014-Rubidium, pubmed-meshheading:12824014-Structure-Activity Relationship
pubmed:year
2003
pubmed:articleTitle
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
pubmed:affiliation
Lilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, IN, USA. engler_thomas@lilly.com
pubmed:publicationType
Journal Article