Linked Life Data

12823958

Source:http://linkedlifedata.com/resource/pubmed/id/12823958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-6-25
pubmed:abstractText
Inverse agonism is emerging as a new endogenous principle for receptor regulation. Agouti-related protein (AgRP), following its release in the brain, stimulates food intake. AgRP binds to brain melanocortin receptors, which are involved in the regulation of body weight. In addition to antagonizing the effects of the melanocortin receptor agonist alpha-melanocyte-stimulating hormone (alpha-MSH), AgRP suppresses the constitutive activity of melanocortin MC(3) and MC(4) receptors, which characterizes AgRP as an inverse agonist rather than a neutral antagonist. The balance between the activity of AgRP-containing neurons and alpha-MSH-containing neurons determines the extent of activation of melanocortin receptors in neurons onto which they project. The identification of AgRP as an endogenous inverse agonist provides physiological relevance to inverse agonism in the control of body weight.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-21
pubmed:dateRevised
2010-5-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Inverse agonism gains weight.
pubmed:affiliation
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. r.a.h.adan@med.uu.nl
pubmed:publicationType
Journal Article, Review