rdf:type |
|
lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0002085,
umls-concept:C0014852,
umls-concept:C0017119,
umls-concept:C0017168,
umls-concept:C0031325,
umls-concept:C0205210,
umls-concept:C0205419,
umls-concept:C0232483,
umls-concept:C0243077,
umls-concept:C0301625,
umls-concept:C0332157,
umls-concept:C0681842,
umls-concept:C1332828,
umls-concept:C1457887,
umls-concept:C1524063
|
pubmed:issue |
12
|
pubmed:dateCreated |
2003-6-25
|
pubmed:abstractText |
The rate of metabolic inactivation of proton-pump inhibitors is determined by polymorphisms of CYP2C19. It is not known if CYP2C19 variant alleles affect responses to proton-pump inhibitor therapy in gastro-oesophageal reflux disease (GERD).
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0269-2813
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1521-8
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:12823155-Adult,
pubmed-meshheading:12823155-Aged,
pubmed-meshheading:12823155-Aged, 80 and over,
pubmed-meshheading:12823155-Alleles,
pubmed-meshheading:12823155-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:12823155-Female,
pubmed-meshheading:12823155-Gastric Acid,
pubmed-meshheading:12823155-Gastroesophageal Reflux,
pubmed-meshheading:12823155-Genotype,
pubmed-meshheading:12823155-Humans,
pubmed-meshheading:12823155-Hydrogen-Ion Concentration,
pubmed-meshheading:12823155-Male,
pubmed-meshheading:12823155-Middle Aged,
pubmed-meshheading:12823155-Mixed Function Oxygenases,
pubmed-meshheading:12823155-Proton Pumps,
pubmed-meshheading:12823155-Risk Factors
|
pubmed:year |
2003
|
pubmed:articleTitle |
CYP2C19 pharmacogenetics in the clinical use of proton-pump inhibitors for gastro-oesophageal reflux disease: variant alleles predict gastric acid suppression, but not oesophageal acid exposure or reflux symptoms.
|
pubmed:affiliation |
Clinical Pharmacology Unit, Division of Gastroenterology and Hepatology and Division of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905, USA. egan.laurence@mayo.edu
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|