Linked Life Data

12820362

Source:http://linkedlifedata.com/resource/pubmed/id/12820362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
2003-6-24
pubmed:abstractText
The novel WHO classification of tumors of hematopoietic and lymphoid tissues highlights the importance of genetic aberrations for the proper diagnosis of these malignancies. Among those techniques allowing detection of chromosomal changes, we have shown repeatedly that interphase fluorescence in situ hybridization (FISH) is currently the most robust and reliable technique for the diagnosis of lymphoma-associated translocations. Interphase FISH assays for the detection of the most frequent chromosomal alterations in myeloid and lymphoid disorders have become commercially available during the recent past. The sensitivity of some of these assays reaches levels below 1% providing valuable tools not only for diagnosis but also for follow-up and detection of minimal residual disease. Improvements of interphase FISH include the development of multicolor interphase FISH assays to detect several of the diagnostic changes in a single cell and of simultaneous fluorescence immunophenotyping (FICTION technique) to correlate phenotypic and genotypic cell features.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1139-48
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Interphase cytogenetics of hematological neoplasms under the perspective of the novel WHO classification.
pubmed:affiliation
Institute of Human Genetics, University Hospital Kiel, Schlerwig-Holstein Campus, Schwanenweg 24, 24105 Kiel, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't