Source:http://linkedlifedata.com/resource/pubmed/id/12820322
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2A
|
pubmed:dateCreated |
2003-6-24
|
pubmed:abstractText |
p53 autoantibodies (AAB) are a new serological parameter with unknown potential in patients with malignancies. The reason why and the mechanism by which they develop is still unclear. So far, only in a limited number of studies has the usefulness of p53 AAB in the follow-up of cancer patients been shown. In this study 32 patients with head and neck cancer, seropositive for p53 AAB in their serum detected with an ELISA, were followed-up for at least 42 months. In 9 out of 32 p53 seropositive AAB head and neck cancer patients a correlation with the clinical course of the disease was seen. The remaining 23 of the p53 AAB-positive patients did not demonstrate any significant AAB titer changes during the follow-up and no significant correlation with the clinical course was observed. In conclusion, the clinical value of p53 AAB as a tumor marker for patients with head and neck cancer seems to be limited.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0250-7005
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
913-5
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:12820322-Adult,
pubmed-meshheading:12820322-Aged,
pubmed-meshheading:12820322-Carcinoma, Squamous Cell,
pubmed-meshheading:12820322-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12820322-Follow-Up Studies,
pubmed-meshheading:12820322-Head and Neck Neoplasms,
pubmed-meshheading:12820322-Humans,
pubmed-meshheading:12820322-Middle Aged,
pubmed-meshheading:12820322-Reproducibility of Results,
pubmed-meshheading:12820322-Tumor Markers, Biological,
pubmed-meshheading:12820322-Tumor Suppressor Protein p53
|
pubmed:articleTitle |
p53 autoantibodies as tumor marker in head and neck squamous cell cancer.
|
pubmed:affiliation |
Department of Otorhinolaryngology, Head and Neck Surgery, University Clinic Kiel, Arnold-Heller-Str. 14, 24105 Kiel, Germany. gottschlich@hno.uni-kiel.de
|
pubmed:publicationType |
Journal Article
|