Linked Life Data

12818685

Source:http://linkedlifedata.com/resource/pubmed/id/12818685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-6-23
pubmed:abstractText
The conformation in solution of 1-phenyl-3-propionamido-1,2,3,4-tetrahydronaphthalene and 1-phenyl-3-(N,N-dimethylamino)-1,2,3,4-tetrahydronaphthalene has been determined by a combination of nuclear magnetic resonance measurements and molecular mechanics calculations. The results indicate that in the cis isomers the cyclohexene ring is in a locked conformation and the trans isomers correspond to a mixture of the two inverted half chairs. Moreover, the data allowed the identification of the two purposely-synthesized geometrical isomers of 1-phenyl-3-propionamidotetralin. Binding studies on melatonin receptor subtypes showed that the (+/-)-cis-1-phenyl-3-propionamido-1,2,3,4-tetrahydronaphthalene has higher affinity and selectivity ratio toward the MT(2) subtype than the (+/-)-trans-isomer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-827X
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Conformation by NMR of two tetralin-based receptor ligands.
pubmed:affiliation
Istituto di Chimica Farmaceutica, Università degli Studi di Urbino, Piazza Rinascimento 6, I-61029 Urbino, Italy. g.gatti@uniurb.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't