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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
14
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|
pubmed:dateCreated |
2003-6-23
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pubmed:abstractText |
A rapid structure-activity study was performed by parallel liquid synthesis on N,N'-disubstitution of 3-amino azepin-2-one to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
|
pubmed:issn |
0968-0896
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
17
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3193-204
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12818682-Alkyl and Aryl Transferases,
pubmed-meshheading:12818682-Amines,
pubmed-meshheading:12818682-Animals,
pubmed-meshheading:12818682-Antineoplastic Agents,
pubmed-meshheading:12818682-Azepines,
pubmed-meshheading:12818682-Cell Line, Tumor,
pubmed-meshheading:12818682-Drug Screening Assays, Antitumor,
pubmed-meshheading:12818682-Enzyme Inhibitors,
pubmed-meshheading:12818682-Farnesyltranstransferase,
pubmed-meshheading:12818682-Imidazoles,
pubmed-meshheading:12818682-Lactams,
pubmed-meshheading:12818682-Mice,
pubmed-meshheading:12818682-Molecular Structure,
pubmed-meshheading:12818682-Rats,
pubmed-meshheading:12818682-Structure-Activity Relationship
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy sur Seine, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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