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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-23
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pubmed:abstractText |
The purpose of this work was to investigate the role of the hepatic and intestinal P-glycoprotein (P-gp) and canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2 (cMOAT/MRP2) on both biliary excretion and intestinal exsorption of irinotecan hydrochloride (CPT-11) and its metabolite, SN-38, in the lactone and carboxylate forms. Cyclosporin A (CsA) was used to modulate P-gp and cMOAT/MRP2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/irinotecan,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance protein 3,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
910-7
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pubmed:dateRevised |
2007-9-25
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pubmed:meshHeading |
pubmed-meshheading:12817897-ATP-Binding Cassette Transporters,
pubmed-meshheading:12817897-Animals,
pubmed-meshheading:12817897-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12817897-Bile,
pubmed-meshheading:12817897-Camptothecin,
pubmed-meshheading:12817897-Chromatography, High Pressure Liquid,
pubmed-meshheading:12817897-Cyclosporine,
pubmed-meshheading:12817897-Digestive System,
pubmed-meshheading:12817897-Epithelium,
pubmed-meshheading:12817897-Immunosuppressive Agents,
pubmed-meshheading:12817897-LLC-PK1 Cells,
pubmed-meshheading:12817897-Liver,
pubmed-meshheading:12817897-Male,
pubmed-meshheading:12817897-Membrane Transport Proteins,
pubmed-meshheading:12817897-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:12817897-P-Glycoprotein,
pubmed-meshheading:12817897-P-Glycoproteins,
pubmed-meshheading:12817897-Perfusion,
pubmed-meshheading:12817897-Rats,
pubmed-meshheading:12817897-Rats, Wistar,
pubmed-meshheading:12817897-Swine,
pubmed-meshheading:12817897-Tissue Distribution
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pubmed:year |
2003
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pubmed:articleTitle |
Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats.
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pubmed:affiliation |
Department of Pharmacy, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan. arimori@post.miyazaki-med.ac.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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