12817889

Source:http://linkedlifedata.com/resource/pubmed/id/12817889

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0040287, umls-concept:C0052970, umls-concept:C0205549, umls-concept:C0220927, umls-concept:C0681842, umls-concept:C1334043, umls-concept:C1511726, umls-concept:C1515655, umls-concept:C1533691, umls-concept:C1707520
pubmed:issue	6
pubmed:dateCreated	2003-6-23
pubmed:abstractText	To evaluate the ability to determine accurate in vivo tissue-to-unbound plasma distribution coefficients (Kpue) from in vitro data.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8406521
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Barbiturates, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0724-8741
pubmed:author	pubmed-author:BallardPeterP, pubmed-author:LeahyDavid EDE, pubmed-author:RowlandMalcolmM
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	864-72
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:12817889-Animals, pubmed-meshheading:12817889-Barbiturates, pubmed-meshheading:12817889-Chemistry, Physical, pubmed-meshheading:12817889-Chromatography, High Pressure Liquid, pubmed-meshheading:12817889-Half-Life, pubmed-meshheading:12817889-Hydrogen-Ion Concentration, pubmed-meshheading:12817889-Indicators and Reagents, pubmed-meshheading:12817889-Infusions, Intravenous, pubmed-meshheading:12817889-Male, pubmed-meshheading:12817889-Mass Spectrometry, pubmed-meshheading:12817889-Molecular Weight, pubmed-meshheading:12817889-Physicochemical Phenomena, pubmed-meshheading:12817889-Rats, pubmed-meshheading:12817889-Rats, Wistar, pubmed-meshheading:12817889-Spectrophotometry, Ultraviolet, pubmed-meshheading:12817889-Structure-Activity Relationship, pubmed-meshheading:12817889-Tissue Distribution
pubmed:year	2003
pubmed:articleTitle	Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.
pubmed:affiliation	Discovery-DMPK, Mereside, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, United Kingdom. peter.ballard@astrazeneca.com
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't