Linked Life Data

12817709

Source:http://linkedlifedata.com/resource/pubmed/id/12817709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-6-23
pubmed:abstractText
To assess the possible involvement of catecholaminergic neurotransmitters in maintenance of spatial cognition, the present work investigated the effects of dopaminergic and noradrenergic receptor antagonists on memory performance of rats in a partially baited radial eight-arm maze. Food-deprived rats were first trained to enter the arms baited with chocolate, and each subject was then randomly assigned to receive further training in either a place version or a cue version of the task. A specific pattern with four arms being baited was used throughout experimentation as the procedure for the place task; whereas four randomly chosen arms, each cued with a piece of sandpaper on the arm entrance, were baited from trial to trial as the procedure of the cue task. For drug evaluation, well-trained subjects were challenged with systemic injections of SCH23390, spiperone, haloperidol, prazosin, yohimbine, and propranolol. Regarding the place task, SCH23390, haloperidol, and propranolol, but not the other three drugs, significantly impaired behavioral performance by increasing the number of arm entries as well as the time to complete the task. The accuracy of performance as measured by the number of entries on the cue task was not significantly affected by any of these drugs tested. However, the times to complete the cue task were significantly increased with all drugs except yohimbine. These data show that blocking different catecholaminergic receptor subtypes produced distinct deficit patterns on the retention performance in a partially baited radial eight-arm maze. Evidently, both D1 and D2 dopamine receptors as well as beta noradrenergic receptors are important in expression of spatial memory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-4920
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-85
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The role of catecholamines in retention performance of a partially baited radial eight-arm maze for rats.
pubmed:affiliation
Department of Psychology, National Cheng-Chi University, Taipei 116, Taiwan, Republic of China. rmliao@nccu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't