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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1993-1-28
|
| pubmed:abstractText |
To test whether foreign gene expression can be improved in transgenic mice by manipulating the site of integration, we co-integrated the efficiently expressed sheep beta-lactoglobulin gene with two poorly expressed beta-lactoglobulin-derived hybrid genes encoding human proteins. In each case, we observed a significant improvement in the frequency and level of expression of the hybrid gene. "Rescuing" transgene expression by co-integration may provide a general solution for improving the efficiency of heterologous gene expression in transgenic animals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
B
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0733-222X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1450-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1281647-Animals,
pubmed-meshheading:1281647-DNA,
pubmed-meshheading:1281647-Gene Expression Regulation,
pubmed-meshheading:1281647-Genetic Engineering,
pubmed-meshheading:1281647-Lactoglobulins,
pubmed-meshheading:1281647-Mice,
pubmed-meshheading:1281647-Mice, Transgenic,
pubmed-meshheading:1281647-Milk Proteins,
pubmed-meshheading:1281647-RNA
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Rescuing transgene expression by co-integration.
|
| pubmed:affiliation |
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, Scotland.
|
| pubmed:publicationType |
Journal Article
|