Linked Life Data

12815747

Source:http://linkedlifedata.com/resource/pubmed/id/12815747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-6-19
pubmed:abstractText
Our objective was to investigate the relationship between the gene encoding the mu-opioid receptor (OPRM1) and susceptibility to substance dependence in European-American (EA) and African-American (AA) subjects. Eight single nucleotide polymorphisms (SNPs) at the OPRM1 locus, i.e., -2044C/A, -1793T/A, -1699insT, -1469T/C, -1320A/G, -111C/T, +17C/T (Ala6Val), and +118A/G (Asn40Asp) were genotyped in 676 subjects: 318 EA subjects and 124 AA subjects with substance dependence, and 179 EA normal controls, and 55 AA normal controls. Affection status was defined by each unique combination of alcohol, cocaine, and opioid dependence and analysis of association examined in relation to the possible combinations. We used a newly implemented permutation method to evaluate statistical significance. In EAs, a significant difference in haplotype frequency distributions was found between controls and "alcohol + opioid" dependent patients (P = 0.0036). This finding is also supported by logistic regression analysis and a simulation method. The frequencies of allele -2044A and haplotypes including -2044A are higher in these patients than in controls. In AAs, no allele, haplotype, or genotype frequencies were significantly different between cases and controls. There were highly significant differences in the allele, haplotype, and genotype frequencies between EA and AA controls. Four of the variants [-1793T/A, -1699insT, -1320A/G, and -111C/T] are in virtually complete linkage disequilibrium (LD) to compose a sequence pattern, which does not associate with any of the seven categories of substance dependence. In EAs, allele -2044A and haplotypes that include -2044A are the susceptibility allele and haplotypes for substance dependence. These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1552-4841
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
120B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-108
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12815747-African Continental Ancestry Group, pubmed-meshheading:12815747-Alcoholism, pubmed-meshheading:12815747-Cocaine-Related Disorders, pubmed-meshheading:12815747-European Continental Ancestry Group, pubmed-meshheading:12815747-Exons, pubmed-meshheading:12815747-Female, pubmed-meshheading:12815747-Gene Frequency, pubmed-meshheading:12815747-Genetic Predisposition to Disease, pubmed-meshheading:12815747-Genetic Variation, pubmed-meshheading:12815747-Genotype, pubmed-meshheading:12815747-Haplotypes, pubmed-meshheading:12815747-Humans, pubmed-meshheading:12815747-Linkage Disequilibrium, pubmed-meshheading:12815747-Male, pubmed-meshheading:12815747-Opioid-Related Disorders, pubmed-meshheading:12815747-Polymorphism, Single Nucleotide, pubmed-meshheading:12815747-Receptors, Opioid, mu, pubmed-meshheading:12815747-Substance-Related Disorders, pubmed-meshheading:12815747-United States
pubmed:year
2003
pubmed:articleTitle
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.
pubmed:affiliation
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA. joel.gelernter@yale.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.