| pubmed-article:1281478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0072402 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0108555 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0600388 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:1281478 | lifeskim:mentions | umls-concept:C0241315 | lld:lifeskim |
| pubmed-article:1281478 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:1281478 | pubmed:dateCreated | 1993-1-21 | lld:pubmed |
| pubmed-article:1281478 | pubmed:abstractText | Incubation of Swiss 3T3 or L929 cells with tumor necrosis factor (TNF) leads to the rapid stimulation of several cytosolic Ser/Thr kinases active toward myelin basic protein, the S6 peptide (RRLSSLR), the G peptide (SPQPSRRGSESSEE), and Kemptide (LRRASLG). This confirms the hypothesis that kinases other than protein kinases A and C may be involved in the TNF signal transduction. Chromatography on Mono Q resolved multiple kinase peaks with each substrate tested and moreover revealed a TNF-mediated casein kinase-2 activation in both cell lines, measurable with the specific RRREEESEEE peptide or with the G peptide. The TNF-stimulated myelin basic protein kinases-1 and -2 were identified as extracellular signal-regulated kinases-2 and -1, respectively, based on their elution pattern on Mono Q chromatography, their inactivation by protein phosphatase action, their reaction with phosphothreonine and phosphotyrosine antibodies, and by their migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as 42- and 44-kDa proteins recognized by anti-extracellular signal-regulated kinase antibodies. | lld:pubmed |
| pubmed-article:1281478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1281478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1281478 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1281478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1281478 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1281478 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:VandenheedeJ... | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:MerlevedeWW | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:FiersWW | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:HaegemanGG | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:AgostinisPP | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:Van LintJJ | lld:pubmed |
| pubmed-article:1281478 | pubmed:author | pubmed-author:VandevoordeVV | lld:pubmed |
| pubmed-article:1281478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1281478 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1281478 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:1281478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1281478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1281478 | pubmed:pagination | 25916-21 | lld:pubmed |
| pubmed-article:1281478 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1281478 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1281478 | pubmed:articleTitle | Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway. | lld:pubmed |
| pubmed-article:1281478 | pubmed:affiliation | Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit te Leuven, Belgium. | lld:pubmed |
| pubmed-article:1281478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1281478 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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