Linked Life Data

12814383

Source:http://linkedlifedata.com/resource/pubmed/id/12814383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-6-19
pubmed:abstractText
The electrophysiological development of hair cells between birth and the eight postnatal day (P8) was studied in the utricular macula of rats gestated in nest boxes mounted upon a centrifuge, subjecting the animals to a gravitational force of 2G. Whole-cell voltage-clamp recordings were made on cells in the acutely isolated epithelium. Cells were accessed through a tear in the epithelium, no enzymatic dissociation procedures were employed. Under artificially enhanced gravity, the whole cell conductance was dramatically altered in the two types of hair cells. Significant increases occurred from P3-4 in the type I cells while in the type II cells, the effect was delayed until P7-8. Fourfold and threefold increases of the mean slope conductance were observed at P7-8 in the type I and type II hair cells, respectively. These results indicate that the electrophysiological properties of a primary transducer such as utricle may be modified by variation of the primary stimulus during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2497-500
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Electrophysiological properties of the utricular primary transducer are modified during development under hypergravity.
pubmed:affiliation
INSERM Unité 583, Physiopathologie et Thérapie des Déficits sensoriels et moteurs, Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier, France. chabbert@univ-montp2.fr
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't