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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-6-18
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pubmed:abstractText |
1,25-Dihydroxyvitamin D(3) inhibits growth of several types of human cancer cells in vitro, but its therapeutic use is hampered because it causes hypercalcemia. 19-nor-1,25-Dihydroxyvitamin D(2) (paricalcitol) is a noncalcemic vitamin D analog that is approved by the Food and Drug Administration for the treatment of secondary hyperparathyroidism. We investigated the antitumor activity and mechanism of action of paricalcitol in vitro and in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1460-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
896-905
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pubmed:dateRevised |
2010-4-29
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pubmed:meshHeading |
pubmed-meshheading:12813173-Animals,
pubmed-meshheading:12813173-Antineoplastic Agents,
pubmed-meshheading:12813173-Apoptosis,
pubmed-meshheading:12813173-Blotting, Western,
pubmed-meshheading:12813173-Cell Cycle,
pubmed-meshheading:12813173-Colonic Neoplasms,
pubmed-meshheading:12813173-Ergocalciferols,
pubmed-meshheading:12813173-Humans,
pubmed-meshheading:12813173-Leukemia,
pubmed-meshheading:12813173-Mice,
pubmed-meshheading:12813173-Mice, Knockout,
pubmed-meshheading:12813173-Mice, Nude,
pubmed-meshheading:12813173-Multiple Myeloma,
pubmed-meshheading:12813173-Polymerase Chain Reaction,
pubmed-meshheading:12813173-Receptors, Calcitriol,
pubmed-meshheading:12813173-Tumor Cells, Cultured,
pubmed-meshheading:12813173-Xenograft Model Antitumor Assays
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pubmed:year |
2003
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pubmed:articleTitle |
Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells.
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pubmed:affiliation |
Division of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, 90048, USA. kumamed1_2001@yahoo.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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