Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-6-17
pubmed:abstractText
Tissue neovascularization involves recruitment of circulating endothelial progenitor cells that originate in the bone marrow. Here, we show that a class of embryonic endothelial progenitor cells (Tie-2+, c-Kit+, Sca-1+, and Flk-1-/low), which were isolated at E7.5 of mouse development at the onset of vasculogenesis, retain their ability to contribute to tumor angiogenesis in the adult. Using intravital fluorescence videomicroscopy, we further defined the multistep process of embryonic endothelial progenitor cell (eEPC) homing and incorporation. Circulating eEPCs are specifically arrested in "hot spots" within the tumor microvasculature, extravasate into the interstitium, form multicellular clusters, and incorporate into functional vascular networks. Expression analysis and in vivo blocking experiments provide evidence that the initial cell arrest of eEPC homing is mediated by E- and P-selectin and P-selectin glycoprotein ligand 1. This paper provides the first in vivo insights into the mechanisms of endothelial progenitor cell recruitment and, thus, indicates novel ways to interfere with pathological neovascularization.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10202935, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10406801, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10436164, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10626664, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10648408, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10725398, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10742145, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10864908, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10905767, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10933068, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-10943840, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11157668, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11390421, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11439179, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11518729, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11559558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11689883, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11827993, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-11901186, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-12189250, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-1384360, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-1760836, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-1934331, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-2953797, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-7626790, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-8082649, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-8689199, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-8985251, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9020076, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9053457, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9109485, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9359693, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9502726, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9591843, http://linkedlifedata.com/resource/pubmed/commentcorrection/12810693-9689079
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1755-65
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis.
pubmed:affiliation
Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't