Linked Life Data

12809433

Source:http://linkedlifedata.com/resource/pubmed/id/12809433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2003-6-17
pubmed:abstractText
Hormesis derives from high metabolic efficiency and hence high fitness that evolve in response to single and multiple environmental agents in low to moderate stress habitats. Consequently, nonlinear fitness continua are an evolutionary expectation for all environmental agents, which invalidates the LNT premise. For ionizing radiation, hormesis is interpreted to be adaptation to background radiation exposures, combined with adaptation to higher radiation exposures dependent on metabolic protection from the array of other abiotic stresses in the environment. This model of radiation hormesis renders suggestions of therapeutic radiation supplementation redundant because of similar health effects from other environmental agents. Furthermore, the model is compatible with a return of exposure levels for radiation protection to higher doses than are presently permissible, a deduction with substantial economic benefits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1040-8444
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Metabolic efficiency in response to environmental agents predicts hormesis and invalidates the linear no-threshold premise: ionizing radiation as a case study.
pubmed:affiliation
La Trobe University, Bundoora, Australia. pparsons@senet.com.au
pubmed:publicationType
Journal Article, Review