Linked Life Data

12808362

Source:http://linkedlifedata.com/resource/pubmed/id/12808362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-6-16
pubmed:abstractText
Preparations from Arnica flowers have been used in traditional medicine since a long time for the treatment of inflammatory diseases. Sesquiterpene lactones are considered as their main active compounds. Previously, it was shown that these natural products attack inflammatory processes at a very central point by inhibiting the transcription factors NF-kappa B and NF-AT at micromolar concentrations. Both transcription factors regulate the transcription of genes encoding for many inflammatory mediators. Thus, these new insights on their molecular mode of action are an important contribution for a better understanding of the antiinflammatory activity of preparations from Arnica. First clinical studies show that they can support the treatment of rheumatic diseases. The agreed use is important to avoid undesirable side effects.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1424-7364
pubmed:author
pubmed:copyrightInfo
Copyright 2003 S. Karger GmbH, Freiburg
pubmed:issnType
Print
pubmed:volume
10 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Arnica: new insights on the molecular mode of action of a traditional medicinal plant].
pubmed:affiliation
Institut für Pharmazeutische Biologie, Freiburg i.Br., Germany. irmgard.merfort@pharmazie.uni-freiburg.de
pubmed:publicationType
Journal Article, English Abstract, Review