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pubmed-article:1280834pubmed:abstractTextWe present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.lld:pubmed
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pubmed-article:1280834pubmed:articleTitleMaximum likelihood estimation and identification directly from single-channel recordings.lld:pubmed
pubmed-article:1280834pubmed:affiliationDepartment of Physics, University of California, San Diego, La Jolla 92093.lld:pubmed
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pubmed-article:1280834pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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