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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1325
|
| pubmed:dateCreated |
1993-1-6
|
| pubmed:abstractText |
We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0962-8452
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
249
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1280834-Animals,
pubmed-meshheading:1280834-Electric Conductivity,
pubmed-meshheading:1280834-Ion Channels,
pubmed-meshheading:1280834-Kinetics,
pubmed-meshheading:1280834-Mathematics,
pubmed-meshheading:1280834-Models, Biological,
pubmed-meshheading:1280834-Probability,
pubmed-meshheading:1280834-Time Factors
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Maximum likelihood estimation and identification directly from single-channel recordings.
|
| pubmed:affiliation |
Department of Physics, University of California, San Diego, La Jolla 92093.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|