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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1993-1-7
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pubmed:abstractText |
Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface protein which mediates adherence of inflammatory cells to target cells by binding with the beta 1-integrin ligand Very Late Antigen-4 (VLA-4) on leukocytes. The expression of VCAM-1 was investigated in a murine model of lupus nephritis, the autoimmune MRL/lpr mouse. Compared with normal mice, MRL/lpr kidneys show increased VCAM-1 expression not only in the endothelium, but also in cortical tubules and glomeruli. Increased steady-state VCAM-1 mRNA levels (approximately 3 kB) are detected in the kidney of nephritic MRL/lpr mice. Two additional transcripts (approximately 2 and approximately 1.8 kB) are present in autoimmune MRL/lpr but not in normal mice. Like ICAM-1, VCAM-1 is also upregulated in vitro in renal cortical tubular and mesangial cells by TNF-alpha, IL-1 and IFN-gamma. T cell and macrophage cell lines adhere to TNF-alpha stimulated tubular epithelial cells by using the VCAM-1/VLA-4 and the ICAM-1/LFA-1 binding pairs. Kidney tissue sections from nephritic MRL/lpr also display increased adhesiveness for T cell and macrophage cell lines, and for MRL/lpr lymph node cells when compared with normal kidney sections. This enhanced adhesiveness of MRL/lpr kidney tissue is inhibited with monoclonal antibodies targeting the VCAM-1 and ICAM-1 molecules. Thus, VCAM-1 and ICAM-1 function as renal parenchymal adhesion molecules and mediate the adherence of pathogenic inflammatory cells in murine lupus nephritis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Very Late Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
903-14
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1280699-Animals,
pubmed-meshheading:1280699-Cell Adhesion,
pubmed-meshheading:1280699-Cell Adhesion Molecules,
pubmed-meshheading:1280699-Female,
pubmed-meshheading:1280699-Intercellular Adhesion Molecule-1,
pubmed-meshheading:1280699-Kidney Tubules,
pubmed-meshheading:1280699-Lupus Nephritis,
pubmed-meshheading:1280699-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:1280699-Mice,
pubmed-meshheading:1280699-Mice, Inbred BALB C,
pubmed-meshheading:1280699-Mice, Inbred C3H,
pubmed-meshheading:1280699-RNA, Messenger,
pubmed-meshheading:1280699-Receptors, Very Late Antigen,
pubmed-meshheading:1280699-Tumor Necrosis Factor-alpha,
pubmed-meshheading:1280699-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1992
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pubmed:articleTitle |
Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis.
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pubmed:affiliation |
Department of Medicine, University of Alabama, Birmingham.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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