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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-6-13
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pubmed:abstractText |
In both pancreatic cancer and chronic pancreatitis, there is enhanced expression of mitogenic growth factors and their tyrosine kinase receptors, which have the capacity to activate mitogen-activated protein kinase (MAPK). In view of the important role of MAPK kinase phosphatase (MKP)-1 in the regulation of MAPK activation, the expression and functional role of MKP-1 was analyzed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DUSP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dual Specificity Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Dusp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1830-45
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12806617-Adolescent,
pubmed-meshheading:12806617-Adult,
pubmed-meshheading:12806617-Aged,
pubmed-meshheading:12806617-Cell Cycle Proteins,
pubmed-meshheading:12806617-Chronic Disease,
pubmed-meshheading:12806617-Down-Regulation,
pubmed-meshheading:12806617-Dual Specificity Phosphatase 1,
pubmed-meshheading:12806617-Epidermal Growth Factor,
pubmed-meshheading:12806617-Female,
pubmed-meshheading:12806617-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12806617-Humans,
pubmed-meshheading:12806617-Immediate-Early Proteins,
pubmed-meshheading:12806617-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12806617-Male,
pubmed-meshheading:12806617-Middle Aged,
pubmed-meshheading:12806617-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12806617-Pancreas,
pubmed-meshheading:12806617-Pancreatic Neoplasms,
pubmed-meshheading:12806617-Pancreatitis,
pubmed-meshheading:12806617-Phosphoprotein Phosphatases,
pubmed-meshheading:12806617-Phosphorylation,
pubmed-meshheading:12806617-Protein Phosphatase 1,
pubmed-meshheading:12806617-Protein Tyrosine Phosphatases,
pubmed-meshheading:12806617-RNA, Messenger,
pubmed-meshheading:12806617-Transfection,
pubmed-meshheading:12806617-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells.
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pubmed:affiliation |
Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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