Source:http://linkedlifedata.com/resource/pubmed/id/12806455
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-6-13
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pubmed:abstractText |
The present investigation was performed to evaluate the susceptibility of seven clones isolated from the highly resistant Colombian strains, prototype of Biodeme Type III. Seven clones previously obtained, showed a phenotypic homogeneity and high similarity with the parental strain. Eight groups of 30 mice were inoculated with one of seven clones or the parental strain; 20 were treated with benznidazole (100mg/kg/day) and 10 were untreated controls. Cure evaluations were done by parasitological and serological tests and PCR. Cure rates varied from 0% (null) to 16.7%. Correlation between positivity of parasitological and serological tests with positive PCR reached 37%. The results demonstrated the high resistance of the clones, suggesting the predominance of a highly resistant principal clone in this strain. The findings apparently indicate that the possibility of cure is minimal for patients infected with this biodeme; a fact that could affect the control of Chagas' disease through treatment of chronically infected people.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0037-8682
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12806455-Animals,
pubmed-meshheading:12806455-Chagas Disease,
pubmed-meshheading:12806455-Cloning, Molecular,
pubmed-meshheading:12806455-Colombia,
pubmed-meshheading:12806455-Drug Resistance,
pubmed-meshheading:12806455-Mice,
pubmed-meshheading:12806455-Nitroimidazoles,
pubmed-meshheading:12806455-Parasitemia,
pubmed-meshheading:12806455-Parasitology,
pubmed-meshheading:12806455-Polymerase Chain Reaction,
pubmed-meshheading:12806455-Trypanocidal Agents,
pubmed-meshheading:12806455-Trypanosoma cruzi
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pubmed:articleTitle |
Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain.
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pubmed:affiliation |
Laboratorio de Doença de Chagas Experimental, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brasil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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