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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5626
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pubmed:dateCreated |
2003-6-13
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pubmed:abstractText |
Cerebellar long-term depression (LTD) is a model of synaptic memory that requires protein kinase C (PKC) activation and is expressed as a reduction in the number of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. LTD was absent in cultured cerebellar Purkinje cells from mutant mice lacking the AMPA receptor GluR2 subunit and could be rescued by transient transfection with the wild-type GluR2 subunit. Transfection with a point mutant that eliminated PKC phosphorylation of Ser880 in the carboxy-terminal PDZ ligand of GluR2 failed to restore LTD. In contrast, transfection with a point mutant that mimicked phosphorylation at Ser880 occluded subsequent LTD. Thus, PKC phosphorylation of GluR2 Ser880 is a critical event in the induction of cerebellar LTD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Grip2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 2,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Prkcabp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/phorbol-12,13-diacetate
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1751-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12805550-Animals,
pubmed-meshheading:12805550-Calcium,
pubmed-meshheading:12805550-Carrier Proteins,
pubmed-meshheading:12805550-Cells, Cultured,
pubmed-meshheading:12805550-Cerebellar Cortex,
pubmed-meshheading:12805550-Enzyme Activation,
pubmed-meshheading:12805550-Excitatory Postsynaptic Potentials,
pubmed-meshheading:12805550-Long-Term Synaptic Depression,
pubmed-meshheading:12805550-Mice,
pubmed-meshheading:12805550-Mice, Knockout,
pubmed-meshheading:12805550-Nerve Tissue Proteins,
pubmed-meshheading:12805550-Nuclear Proteins,
pubmed-meshheading:12805550-Nuclear Receptor Coactivator 2,
pubmed-meshheading:12805550-Patch-Clamp Techniques,
pubmed-meshheading:12805550-Phorbol Esters,
pubmed-meshheading:12805550-Phosphorylation,
pubmed-meshheading:12805550-Phosphoserine,
pubmed-meshheading:12805550-Point Mutation,
pubmed-meshheading:12805550-Protein Binding,
pubmed-meshheading:12805550-Protein Kinase C,
pubmed-meshheading:12805550-Purkinje Cells,
pubmed-meshheading:12805550-Receptors, AMPA,
pubmed-meshheading:12805550-Transcription Factors,
pubmed-meshheading:12805550-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.
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pubmed:affiliation |
Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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