Linked Life Data

12804445

Source:http://linkedlifedata.com/resource/pubmed/id/12804445

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-6-13
pubmed:abstractText
Cocaine dependence is a common and serious condition, which has become a substantial public health problem. The past decade has witnessed a sustained search for an effective pharmacotherapeutic agent for the treatment of cocaine dependence. While administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. Post-cocaine use depression and cocaine craving may be linked to this down-regulation. Antidepressant pharmacotherapy, by augmenting monoamine levels, may alleviate cocaine abstinence symptomatology, as well as relieving dysphoria and associated craving by general antidepressant action.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1469-493X
pubmed:author
pubmed:issnType
Electronic
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
CD002950
pubmed:dateRevised
2010-3-24
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Antidepressants for cocaine dependence.
pubmed:affiliation
Department of Mental Health, Universidade Federal de Pelotas, Av. Duque de Caxias, 250, Pelotas, Rio Grande do Sul, Brazil. mslima@nutecnet.com.br
pubmed:publicationType
Journal Article, Review