| pubmed-article:12803478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12803478 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:12803478 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:12803478 | lifeskim:mentions | umls-concept:C0034963 | lld:lifeskim |
| pubmed-article:12803478 | lifeskim:mentions | umls-concept:C0087071 | lld:lifeskim |
| pubmed-article:12803478 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:12803478 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12803478 | pubmed:dateCreated | 2003-6-13 | lld:pubmed |
| pubmed-article:12803478 | pubmed:abstractText | The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-deficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis. | lld:pubmed |
| pubmed-article:12803478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12803478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12803478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12803478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12803478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12803478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12803478 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12803478 | pubmed:issn | 1016-8478 | lld:pubmed |
| pubmed-article:12803478 | pubmed:author | pubmed-author:RudolphKarl... | lld:pubmed |
| pubmed-article:12803478 | pubmed:author | pubmed-author:LeeHan-WoongH... | lld:pubmed |
| pubmed-article:12803478 | pubmed:author | pubmed-author:DjojosubrotoM... | lld:pubmed |
| pubmed-article:12803478 | pubmed:author | pubmed-author:ChoiYoon... | lld:pubmed |
| pubmed-article:12803478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12803478 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:12803478 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:12803478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12803478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12803478 | pubmed:pagination | 164-75 | lld:pubmed |
| pubmed-article:12803478 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:meshHeading | pubmed-meshheading:12803478... | lld:pubmed |
| pubmed-article:12803478 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12803478 | pubmed:articleTitle | Telomeres and telomerase in aging, regeneration and cancer. | lld:pubmed |
| pubmed-article:12803478 | pubmed:affiliation | Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover Carl-Neuberg-Str. 1 30625 Hannover, Germany. | lld:pubmed |
| pubmed-article:12803478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12803478 | pubmed:publicationType | Review | lld:pubmed |
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