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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-12-24
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pubmed:abstractText |
The effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists dizocilpine and phenycyclidine, the competitive NMDA antagonist 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and the antagonist at the glycine modulatory site of the NMDA receptor, 3-amino-1-hydroxy-2-pyrrolidone (HA-966) on the long lasting attenuation of some post-synaptic 5-HT1A receptor-mediated responses in rats (increased corticosterone secretion and inhibition of the cage leaving response) produced by a single injection of the 5-hydroxytryptamine1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was studied. It was found that these antagonists counteracted the attenuation of these responses at dose levels known to block the NMDA receptor-ion channel complex in vivo. It is concluded that the long lasting attenuation of postsynaptic responses after a 5-HT1A receptor agonist is initiated through stimulation of glutamate NMDA receptors indicating a functional interaction between the 5-HT and glutamate systems in at least two different models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-carboxypiperazin-4-yl)propyl-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/HA 966,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Phencyclidine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-1298
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
346
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
138-43
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1280336-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:1280336-Animals,
pubmed-meshheading:1280336-Behavior, Animal,
pubmed-meshheading:1280336-Corticosterone,
pubmed-meshheading:1280336-Dizocilpine Maleate,
pubmed-meshheading:1280336-Ion Channels,
pubmed-meshheading:1280336-Male,
pubmed-meshheading:1280336-Phencyclidine,
pubmed-meshheading:1280336-Piperazines,
pubmed-meshheading:1280336-Pyrrolidinones,
pubmed-meshheading:1280336-Rats,
pubmed-meshheading:1280336-Rats, Sprague-Dawley,
pubmed-meshheading:1280336-Receptors, Glutamate,
pubmed-meshheading:1280336-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1280336-Receptors, Serotonin,
pubmed-meshheading:1280336-Shivering,
pubmed-meshheading:1280336-Synapses
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pubmed:year |
1992
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pubmed:articleTitle |
N-methyl-D-aspartate receptor antagonists counteract the long lasting 5-HT1A receptor-induced attenuation of postsynaptic responses in the rat in vivo.
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pubmed:affiliation |
Research Laboratories, Astra Arcus AB, Södertälje, Sweden.
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pubmed:publicationType |
Journal Article
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