| pubmed-article:1280266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C0016055 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:1280266 | lifeskim:mentions | umls-concept:C1512693 | lld:lifeskim |
| pubmed-article:1280266 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:1280266 | pubmed:dateCreated | 1992-12-30 | lld:pubmed |
| pubmed-article:1280266 | pubmed:abstractText | We have previously reported an anti-fibronectin monoclonal antibody (mAb) (BC-1) which reacts with an ED-B-containing beta-galactosidase-fibronectin fusion protein but not with an identical beta-galactosidase-fibronectin fusion protein in which the ED-B sequence is omitted. In further experiments aimed at localizing more precisely the epitope recognized by this mAb, we demonstrate that 1) the mAb BC-1 is indeed specific for ED-B-containing fibronectin (FN) molecules even though the epitope recognized by this mAb is localized on the type III homology repeat 7 (the one which precedes the ED-B sequence) and 2) in fibronectin molecules lacking the ED-B sequence, this epitope is masked. We further demonstrate that, to mask the epitope recognized by the mAb BC-1, the presence of at least half of the FN type III homology repeat 9 is necessary. We also report the production of the mAb IST-6 which recognizes only FN molecules in which the ED-B sequence is lacking. These data clearly demonstrate that the presence of the ED-B sequence within FN molecules generates conformational modification in the central part of the molecules that unmasks previously cryptic sequences and masks others. | lld:pubmed |
| pubmed-article:1280266 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1280266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1280266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1280266 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1280266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1280266 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1280266 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1280266 | pubmed:author | pubmed-author:ZardiLL | lld:pubmed |
| pubmed-article:1280266 | pubmed:author | pubmed-author:CarnemollaBB | lld:pubmed |
| pubmed-article:1280266 | pubmed:author | pubmed-author:LepriniAA | lld:pubmed |
| pubmed-article:1280266 | pubmed:author | pubmed-author:AllemanniGG | lld:pubmed |
| pubmed-article:1280266 | pubmed:author | pubmed-author:SaginatiMM | lld:pubmed |
| pubmed-article:1280266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1280266 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1280266 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:1280266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1280266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1280266 | pubmed:pagination | 24689-92 | lld:pubmed |
| pubmed-article:1280266 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1280266 | pubmed:meshHeading | pubmed-meshheading:1280266-... | lld:pubmed |
| pubmed-article:1280266 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1280266 | pubmed:articleTitle | The inclusion of the type III repeat ED-B in the fibronectin molecule generates conformational modifications that unmask a cryptic sequence. | lld:pubmed |
| pubmed-article:1280266 | pubmed:affiliation | Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. | lld:pubmed |
| pubmed-article:1280266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1280266 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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