Linked Life Data

12802197

Source:http://linkedlifedata.com/resource/pubmed/id/12802197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-6-12
pubmed:abstractText
The early response of mammalian cells to growth factors consists of a combination of protein assemblages and kinase cascades. In the study of how signal specificity of different growth factors is determined, PC12 cells represent an elective experimental model to compare the signaling of differentiative nerve growth factor (NGF) and mitogenic epidermal growth factor (EGF). Focusing on Shc as established regulator of the Ras-ERK cascade, whose sustained activation is known to critically shape the neuronal differentiation of PC12 cells, the present manuscript describes two novel sources of divergence in the signaling of NGF and EGF: a differential phosphorylation of p66-Shc at early time points and a differential duration in the recruitment of the overall pool of Shc.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1031-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Divergence in the upstream signaling of nerve growth factor (NGF) and epidermal growth factor (EGF).
pubmed:affiliation
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't