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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-12
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pubmed:abstractText |
The p210 bcr-abl fusion protein has a key role in the pathogenesis of chronic myeloid leukemia (CML). However, its influence on disease progression to blast crisis is marginal and mostly due to its effect of impairing the genomic stability of clonal myeloid progenitors through pathways still largely unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin B,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
622-30
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12801837-Aneuploidy,
pubmed-meshheading:12801837-Animals,
pubmed-meshheading:12801837-CDC2 Protein Kinase,
pubmed-meshheading:12801837-Cell Cycle,
pubmed-meshheading:12801837-Clone Cells,
pubmed-meshheading:12801837-Cyclin B,
pubmed-meshheading:12801837-Fusion Proteins, bcr-abl,
pubmed-meshheading:12801837-Gene Expression,
pubmed-meshheading:12801837-Genome,
pubmed-meshheading:12801837-Kinetics,
pubmed-meshheading:12801837-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:12801837-Mice,
pubmed-meshheading:12801837-Myeloid Progenitor Cells,
pubmed-meshheading:12801837-Oncogene Proteins, Viral,
pubmed-meshheading:12801837-Ploidies,
pubmed-meshheading:12801837-Polyploidy,
pubmed-meshheading:12801837-Protein-Tyrosine Kinases,
pubmed-meshheading:12801837-Repressor Proteins,
pubmed-meshheading:12801837-Tumor Suppressor Protein p53
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pubmed:year |
2003
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pubmed:articleTitle |
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
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pubmed:affiliation |
Istituto di Ematologia e Oncologia Medica "Lorenzo e Ariosto Seràgnoli", University of Bologna Medical School, Bologna, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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