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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-12-4
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pubmed:abstractText |
Platelet-derived growth factor (PDGF) AB and BB isoforms were potent mitogens for cultured vascular smooth muscle cells from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). PDGF-AA promotes protein synthesis in a dose-dependent manner in SHR cells, whereas DNA synthesis was stimulated only slightly. However, this isoform did not activate either DNA or protein synthesis in WKY cells. PDGF-AA stimulated tyrosine phosphorylation of its receptor protein and phospholipase C-gamma 1 in SHR cell but not in WKY cells. These results indicate that vascular smooth muscle cell of SHR is uniquely responsive to PDGF-AA, presumably due to abnormality in receptor expression, in its hypertrophic response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Uridine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
188
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
524-30
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1280116-Animals,
pubmed-meshheading:1280116-Aorta, Thoracic,
pubmed-meshheading:1280116-DNA,
pubmed-meshheading:1280116-Female,
pubmed-meshheading:1280116-Humans,
pubmed-meshheading:1280116-Isoenzymes,
pubmed-meshheading:1280116-Kinetics,
pubmed-meshheading:1280116-Macromolecular Substances,
pubmed-meshheading:1280116-Muscle, Smooth, Vascular,
pubmed-meshheading:1280116-Phosphoproteins,
pubmed-meshheading:1280116-Phosphorylation,
pubmed-meshheading:1280116-Platelet-Derived Growth Factor,
pubmed-meshheading:1280116-Protein Biosynthesis,
pubmed-meshheading:1280116-RNA,
pubmed-meshheading:1280116-Rats,
pubmed-meshheading:1280116-Rats, Inbred SHR,
pubmed-meshheading:1280116-Rats, Inbred WKY,
pubmed-meshheading:1280116-Recombinant Proteins,
pubmed-meshheading:1280116-Structure-Activity Relationship,
pubmed-meshheading:1280116-Thymidine,
pubmed-meshheading:1280116-Tritium,
pubmed-meshheading:1280116-Type C Phospholipases,
pubmed-meshheading:1280116-Uridine
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pubmed:year |
1992
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pubmed:articleTitle |
Platelet-derived growth factor AA homodimer stimulates protein synthesis rather than DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats but not from normotensive rats.
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pubmed:affiliation |
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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