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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-6-12
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pubmed:abstractText |
In this report, the controversy concerning the sensitivity of dendritic cells (DCs) to Fas-dependent induction of apoptosis was examined using murine DCs. Although DCs could not be lysed when exposed to an anti-Fas antibody, Jo2, the observed resistance turned out to reflect their lack of the expression of Fc(gamma)R necessary for crosslinking the antibody, rather than their intrinsic resistance. Thus, at least a fraction of DCs was sensitive to Jo2 in the presence of Fc(gamma)R-expressing by-standers. Consistently, a significant fraction of DCs was sensitive to Fas-dependent lysis mediated by T cells including the antigen-specific killing by CD4+ T cells. Both immature (class II MHClow) and mature (class II MHChigh) DCs were sensitive to the Fas-based induction of apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0385-5600
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12801066-Animals,
pubmed-meshheading:12801066-Antibodies, Monoclonal,
pubmed-meshheading:12801066-Antigens, CD4,
pubmed-meshheading:12801066-Antigens, CD95,
pubmed-meshheading:12801066-Apoptosis,
pubmed-meshheading:12801066-Bone Marrow Cells,
pubmed-meshheading:12801066-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12801066-Cells, Cultured,
pubmed-meshheading:12801066-Cytotoxicity, Immunologic,
pubmed-meshheading:12801066-Dendritic Cells,
pubmed-meshheading:12801066-Drug Resistance,
pubmed-meshheading:12801066-Flow Cytometry,
pubmed-meshheading:12801066-Humans,
pubmed-meshheading:12801066-Interferon-gamma,
pubmed-meshheading:12801066-Mice,
pubmed-meshheading:12801066-Mice, Inbred BALB C,
pubmed-meshheading:12801066-Mice, Inbred C3H,
pubmed-meshheading:12801066-Receptors, IgG,
pubmed-meshheading:12801066-Spleen
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pubmed:year |
2003
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pubmed:articleTitle |
Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody.
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pubmed:affiliation |
Department of Immunology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228-8555, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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