Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-6-11
pubmed:abstractText
The S100A4 protein has been associated with increased metastatic capacity of cancer cells, and recent studies have suggested a correlation between the expression level of S100A4 and the prognostic outcome for patients with various types of cancer. The knowledge about the mechanisms underlying the metastasis-promoting effects is still limited, and the aim of the present study was to elucidate signal transduction pathways involved in the regulation of S100A4. After treatment of human carcinoma cells with interferon-gamma (IFN-gamma), we observed downregulation of S100A4 both at mRNA and protein levels. The effect was not dependent on IFN-gamma-induced apoptosis or IFN-gamma-mediated cell cycle arrest. Moreover, IFN-gamma-mediated decrease in mRNA stability could not account for the observed decrease in S100A4 transcript level. Finally, microarray analysis suggests ISGF3G, ETV5, ZNF133 and CEBPG as possible candidate genes involved in IFN-gamma-mediated repression of S100A4.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10389988, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10429967, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10493528, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10749128, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10753920, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-10811984, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11106237, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11108967, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11251165, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11278647, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11498791, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11527429, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11585785, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11836260, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11839590, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-11956586, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-12404222, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-3459716, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-7649249, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-8455951, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-8504859, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-8968106, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9143706, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9274623, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9343424, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9545325, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9649437, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9759489, http://linkedlifedata.com/resource/pubmed/commentcorrection/12799648-9759666
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1995-2001
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest.
pubmed:affiliation
Department of Tumour Biology, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't