Linked Life Data

12799283

Source:http://linkedlifedata.com/resource/pubmed/id/12799283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-6-11
pubmed:abstractText
Migration of hematopoietic stem and progenitor cells (HPCs) is controlled by chemotactic factors released in the hematopoietic microenvironment. In particular, the chemokine SDF-1, which activates the G protein-coupled receptor (GPR) CXCR4, plays an important role in progenitor cell mobilization and homing. However, we provide evidence that ligands of other GPRs similarly act on CD34(+) hematopoietic progenitors. These ligands comprise non-peptide mediators, including the cysteinyl-leukotriene receptor CysLT1, and stimulate migration and integrin-dependent adhesion of HPCs. Moreover, continuous activation of a GPR by a specific ligand upregulates the responsiveness of other GPRs to their corresponding ligands. These findings suggest that HPC migration may not depend on a single chemokine receptor (e.g., CXCR4). Rather, mobilization and homing of HPCs involve several GPRs, which interact with each other as well as with adhesion molecules. Pharmacological activation and inhibition of the GPR may allow HPC mobilization and homing to be modulated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
996
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Nonpeptide mediators in the hematopoietic microenvironment.
pubmed:affiliation
Department of Medicine II, University of Tübingen, Tübingen, Germany. robert.moehle@med.uni-tuebingen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't