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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2003-6-11
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pubmed:abstractText |
In a previous report, we have provided evidence that novel anti-malarial compounds based on 2,5-diaminobenzophenone farnesyltransferase inhibitors might benefit from the presence of a polar moiety at the para position of the terminal phenyl of the arylfurylacryloyl partial structure. Here, we demonstrate that different moieties with hydrogen bond acceptor properties lead to equipotent or even improved anti-malarial activity in comparison to the nitro group described before.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2159-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12798326-Acrylates,
pubmed-meshheading:12798326-Alkyl and Aryl Transferases,
pubmed-meshheading:12798326-Amides,
pubmed-meshheading:12798326-Animals,
pubmed-meshheading:12798326-Antimalarials,
pubmed-meshheading:12798326-Enzyme Inhibitors,
pubmed-meshheading:12798326-Farnesyltranstransferase,
pubmed-meshheading:12798326-Furans,
pubmed-meshheading:12798326-Hydrogen Bonding,
pubmed-meshheading:12798326-Indicators and Reagents,
pubmed-meshheading:12798326-Plasmodium falciparum,
pubmed-meshheading:12798326-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties.
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pubmed:affiliation |
Biochemisches Institut der Universität Giessen, Friedrichstrasse 24, D-35249, Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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