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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-12-7
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pubmed:abstractText |
SP-antagonistic properties of a newly synthesized peptide Tyr-Pro-D-Phe-Phe-D-Phe-D-Trp-MetNH2 (AWL-60) were investigated both in vitro and in vivo. In vitro AWL-60 effectively antagonized the action of SP-agonist (SP6-11); however, this antagonism was non-competitive. Antagonistic properties of AWL-60 were also observed in vivo: in doses as low as 0.1 nmol/kg iv AWL-60 markedly attenuated the fall in blood pressure produced by [less than Glu]6SP6-11. Since AWL-60 exerts weak opioid agonistic properties (as a casomorphine analog) the possible involvement of an opioid agonistic component in their SP inhibitory action is considered.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1279644-Amino Acid Sequence,
pubmed-meshheading:1279644-Animals,
pubmed-meshheading:1279644-Blood Pressure,
pubmed-meshheading:1279644-Cross-Linking Reagents,
pubmed-meshheading:1279644-Endorphins,
pubmed-meshheading:1279644-Guinea Pigs,
pubmed-meshheading:1279644-Ileum,
pubmed-meshheading:1279644-Isometric Contraction,
pubmed-meshheading:1279644-Male,
pubmed-meshheading:1279644-Molecular Sequence Data,
pubmed-meshheading:1279644-Muscle, Smooth,
pubmed-meshheading:1279644-Oligopeptides,
pubmed-meshheading:1279644-Peptide Fragments,
pubmed-meshheading:1279644-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:1279644-Rats,
pubmed-meshheading:1279644-Rats, Wistar,
pubmed-meshheading:1279644-Substance P
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pubmed:articleTitle |
Bifunctional pharmacophores. Biological activities of the peptide analog containing both casomorphine-like and substance P antagonist-like active elements.
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pubmed:affiliation |
Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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