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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-10
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|
pubmed:abstractText |
T helper (Th) 1/Th2 balance, controlled by Th1 or Th2 cells producing cytokines, plays important roles in antitumor immunity. Interleukin-18 (IL-18) can act together with IL-12 in promoting the generation of IFN-gamma producing Th1 cells. The goal of this study was to determine whether cytotoxic T lymphocyte (CTL) secreted in a murine IL-18-induced Th1-dominant state inhibited the development of primary tumors and synchronous liver metastases in orthotopic colon cancer model.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
9
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2357-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12796406-Adenoviridae,
pubmed-meshheading:12796406-Animals,
pubmed-meshheading:12796406-Colonic Neoplasms,
pubmed-meshheading:12796406-Female,
pubmed-meshheading:12796406-Gene Therapy,
pubmed-meshheading:12796406-Immunotherapy, Adoptive,
pubmed-meshheading:12796406-Interleukin-18,
pubmed-meshheading:12796406-Lymphocyte Activation,
pubmed-meshheading:12796406-Mice,
pubmed-meshheading:12796406-Mice, Inbred BALB C,
pubmed-meshheading:12796406-Neovascularization, Pathologic,
pubmed-meshheading:12796406-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12796406-Th1 Cells,
pubmed-meshheading:12796406-Transduction, Genetic
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pubmed:year |
2003
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|
pubmed:articleTitle |
Intensification of antitumor effect by T helper 1-dominant adoptive immunogene therapy for advanced orthotopic colon cancer.
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pubmed:affiliation |
Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641-8510, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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