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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
2003-6-10
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pubmed:abstractText |
Microvasculitis may play a greater part in the pathogenesis of paraproteinaemic neuropathies than is generally recognised, producing tissue destruction by convergent immune and physical mechanisms. We present a patient with a clinical syndrome of mononeuritis multiplex and a circulating IgM lambda paraprotein, in whom bone marrow aspiration revealed a lymphoplasmacytoid lymphoma. Microvasculitic changes were present in the first nerve biopsy, and the second showed extensive destruction of neural architecture and deposition of IgM-related material. A 2-stage pathogenic cascade is postulated and explored with a review of the relevant literature.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1085-9489
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
100-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12795714-Aged,
pubmed-meshheading:12795714-Antigens, CD3,
pubmed-meshheading:12795714-Electrophysiologic Techniques, Cardiac,
pubmed-meshheading:12795714-Endothelium,
pubmed-meshheading:12795714-Fascia,
pubmed-meshheading:12795714-Humans,
pubmed-meshheading:12795714-Immunoglobulin M,
pubmed-meshheading:12795714-Lymphoma, B-Cell,
pubmed-meshheading:12795714-Male,
pubmed-meshheading:12795714-Microcirculation,
pubmed-meshheading:12795714-Microscopy, Electron,
pubmed-meshheading:12795714-Mononeuropathies,
pubmed-meshheading:12795714-Neural Conduction,
pubmed-meshheading:12795714-Paraproteinemias,
pubmed-meshheading:12795714-Paraproteins,
pubmed-meshheading:12795714-Polyneuropathies,
pubmed-meshheading:12795714-Review Literature as Topic,
pubmed-meshheading:12795714-Vasculitis
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pubmed:year |
2003
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|
pubmed:articleTitle |
Microvasculitic paraproteinaemic polyneuropathy and B-cell lymphoma.
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|
pubmed:affiliation |
Department of Neurology, Institute of Psychiatry, King's College, De Crespigny Park, London SE5 8AF, UK. m.turner@iop.kcl.ac.uk
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pubmed:publicationType |
Journal Article,
Case Reports
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