|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1992-12-8
|
|
pubmed:abstractText |
We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0950-9232
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:geneSymbol |
KIT
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2207-17
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1279499-Amino Acid Sequence,
pubmed-meshheading:1279499-Base Sequence,
pubmed-meshheading:1279499-Genes, fms,
pubmed-meshheading:1279499-Genetic Linkage,
pubmed-meshheading:1279499-Humans,
pubmed-meshheading:1279499-Molecular Sequence Data,
pubmed-meshheading:1279499-Promoter Regions, Genetic,
pubmed-meshheading:1279499-Proto-Oncogene Proteins,
pubmed-meshheading:1279499-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:1279499-Proto-Oncogenes,
pubmed-meshheading:1279499-RNA, Messenger,
pubmed-meshheading:1279499-RNA Splicing,
pubmed-meshheading:1279499-Receptors, Platelet-Derived Growth Factor
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene.
|
|
pubmed:affiliation |
Department of Medical Genetics, University of Wisconsin, Madison 53706.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
