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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1992-12-18
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pubmed:abstractText |
Globus pallidus neurons were dissociated from adult rats and recorded in whole-cell voltage-clamp mode. In tetrodotoxin- and cadmium-added bath, outward potassium conductances were evaluated. Depolarization activated large and predominantly sustained currents, with little inactivation. The transient outward current was isolated through its voltage-dependency, kinetics and pharmacology. A-like current activated around -45 mV and decayed exponentially with a time-constant of about 50 ms at 0 mV. Steady-state half-inactivation voltage was about -60 mV, suggesting that A-current was not fully inactivated at rest. 4-Aminopyridine sensitivity of the transient outward current was in the low millimolar range. A-current might play a relevant role in shaping firing properties of pallidal neurons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1279487-4-Aminopyridine,
pubmed-meshheading:1279487-Animals,
pubmed-meshheading:1279487-Electrophysiology,
pubmed-meshheading:1279487-Globus Pallidus,
pubmed-meshheading:1279487-Ion Channels,
pubmed-meshheading:1279487-Male,
pubmed-meshheading:1279487-Neurons,
pubmed-meshheading:1279487-Rats,
pubmed-meshheading:1279487-Rats, Wistar
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pubmed:year |
1992
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pubmed:articleTitle |
A-current in rat globus pallidus: a whole-cell voltage clamp study on acutely dissociated neurons.
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pubmed:affiliation |
Clinica Neurologica, II Università degli Studi di Roma Tor Vergata, Italy.
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pubmed:publicationType |
Journal Article
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