Linked Life Data

12794693

Source:http://linkedlifedata.com/resource/pubmed/id/12794693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-6-9
pubmed:abstractText
Monozygotic (MZ) twins account for about one-third of all twins. Most MZ twins arise sporadically but there are familial occurrences. The causes of MZ twinning are largely speculative but involve both genetic and environmental factors. Genetic factors could include cell adhesion molecules and factors involved in growth and differentiation of the placenta and fetus. In this study, we examine the possible role of E-cadherin, a cell adhesion molecule, in the causation of twinning. A common polymorphism in the E-cadherin gene reduces expression of E-cadherin by up to 68%. We examined the E-cadherin polymorphism in DNA extracted from placental tissue from 121 MZ twins, 99 DZ twins, and 93 singletons. There was no significant difference in the distribution of the E-cadherin polymorphism in MZ twins although there was a slight over-representation of homozygotes for the polymorphism in MZ twins. We conclude that there is insufficient evidence to suggest that decreased E-cadherin expression alone is a causative factor in MZ twinning but it could be a contributory factor along with other genetic and environmental influences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1552-4825
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
120A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-62
pubmed:dateRevised
2008-5-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Mechanisms of monozygotic (MZ) twinning: a possible role for the cell adhesion molecule, E-cadherin.
pubmed:affiliation
Department of Laboratory Medicine and Pathology, University of Alberta Hospital, 8440-112 Street, Edmonton, Alberta, Canada T6G 2B7. fiona.bamforth@ualberta.ca
pubmed:publicationType
Journal Article