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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6398
|
| pubmed:dateCreated |
1992-12-1
|
| pubmed:abstractText |
The glycoprotein P-selectin is a cell adhesion molecule of stimulated platelets and endothelial cells, which mediates the interaction of these cells with neutrophils and monocytes. It is a membrane component of cell storage granules, and is a member of the selectin family which includes E-selectin and L-selectin. P-selectin recognizes both lineage-specific carbohydrate ligands on monocytes and neutrophils, including the Lewis x antigen, sialic acid, and a protein component. In inflammation and thrombosis, P-selectin may mediate the interaction of leukocytes with platelets bound in the region of tissue injury and with stimulated endothelium. To evaluate the role of P-selectin in platelet-leukocyte adhesion in vivo, the accumulation of leukocytes within an experimental thrombus was explored in an arteriovenous shunt model in baboons. A Dacron graft implanted within an arteriovenous shunt is thrombogenic, accumulating platelets and fibrin within its lumen. These bound platelets express P-selectin. Here we show that antibody inhibition of leukocyte binding to P-selectin expressed on platelets immobilized on the graft blocks leukocyte accumulation and inhibits the deposition of fibrin within the thrombus. These results indicate that P-selectin is an important adhesion molecule on platelets, mediating platelet-leukocyte binding in vivo, that the presence of leukocytes in thrombi is mediated by P-selectin, and that these leukocytes promote fibrin deposition.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrin,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Terephthalates
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
359
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
848-51
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1279433-Animals,
pubmed-meshheading:1279433-Antibodies, Monoclonal,
pubmed-meshheading:1279433-Arteriovenous Shunt, Surgical,
pubmed-meshheading:1279433-Blood Platelets,
pubmed-meshheading:1279433-Cell Adhesion Molecules,
pubmed-meshheading:1279433-Fibrin,
pubmed-meshheading:1279433-Humans,
pubmed-meshheading:1279433-Kinetics,
pubmed-meshheading:1279433-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:1279433-Leukocytes,
pubmed-meshheading:1279433-Mice,
pubmed-meshheading:1279433-Mice, Inbred BALB C,
pubmed-meshheading:1279433-Microscopy, Electron, Scanning,
pubmed-meshheading:1279433-P-Selectin,
pubmed-meshheading:1279433-Papio,
pubmed-meshheading:1279433-Platelet Adhesiveness,
pubmed-meshheading:1279433-Platelet Membrane Glycoproteins,
pubmed-meshheading:1279433-Polyethylene Terephthalates,
pubmed-meshheading:1279433-Tumor Cells, Cultured
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets.
|
| pubmed:affiliation |
Center for Hemostasis and Thrombosis Research, New England Medical Center, Boston, Massachusetts.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|