Linked Life Data

12794308

Source:http://linkedlifedata.com/resource/pubmed/id/12794308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-6-9
pubmed:abstractText
The presence of pituitary adenylate cyclase-activating polypeptide (PACAP) and its mRNAin the three levels of the hypothalamo-hypophyseal-ovarian axis was previously demonstrated using immunohistochemistry, in situ hybridization, and reverse transcriptase polymerase chain reaction (RT-PCR). In the hypothalamus, PACAP is present in neuroendocrine effector cells and in the median eminence. In the anterior pituitary and ovary, PACAP is transiently present during the proestrous stage of the estrous cycle. In the pituitary, PACAP was observed in gonadotropes. In the ovary, PACAP was demonstrated in the granulosa cells of the preovulatory ovarian follicles. The effect of PACAP on luteinizing hormone (LH) secretion was demonstrated in in vivo and in vitro models. In our work we have studied the role of PACAP in gonadotropic hormone secretion at hypothalamic and pituitary levels. At the hypothalamic level, PACAP, administered intracerebroventricularly to female rats before the critical period of the proestrus stage, can inhibit LH release and ovulation. Its inhibiting effect is mediated through corticotropin-releasing factor (CRF) and endogenous opioids. PACAP administered to neonatal female rats delayed the onset of puberty by influencing the luteinizing hormone-releasing hormone (LHRH) neuronal system. In the pituitary gland, the release of PACAP depended on the stage of the estrous cycle and on the time of day the animals were sacrificed. On the day of proestrus, the number of PACAP-releasing cells showed a diurnal change with two peaks (in the morning and in the evening). The peak was much higher in the evening at the end of the LH surge than in the morning.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0895-8696
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-52
pubmed:dateRevised
2010-4-12
pubmed:meshHeading
pubmed-meshheading:12794308-Animals, pubmed-meshheading:12794308-Animals, Newborn, pubmed-meshheading:12794308-Corticotropin-Releasing Hormone, pubmed-meshheading:12794308-Estrous Cycle, pubmed-meshheading:12794308-Female, pubmed-meshheading:12794308-GABA Agonists, pubmed-meshheading:12794308-GABA Antagonists, pubmed-meshheading:12794308-Gonadotropin-Releasing Hormone, pubmed-meshheading:12794308-Gonadotropins, pubmed-meshheading:12794308-Hypothalamo-Hypophyseal System, pubmed-meshheading:12794308-Hypothalamus, pubmed-meshheading:12794308-Injections, Intraventricular, pubmed-meshheading:12794308-Luteinizing Hormone, pubmed-meshheading:12794308-Narcotic Antagonists, pubmed-meshheading:12794308-Neuropeptides, pubmed-meshheading:12794308-Ovulation, pubmed-meshheading:12794308-Pituitary Adenylate Cyclase-Activating Polypeptide, pubmed-meshheading:12794308-Pituitary Gland, Anterior, pubmed-meshheading:12794308-Proestrus, pubmed-meshheading:12794308-Rats, pubmed-meshheading:12794308-Rats, Sprague-Dawley, pubmed-meshheading:12794308-Somatostatin
pubmed:year
2003
pubmed:articleTitle
The role of PACAP in gonadotropic hormone secretion at hypothalamic and pituitary levels.
pubmed:affiliation
Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. koves@ana2.sote.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't