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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-6-9
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pubmed:abstractText |
Pulmonary eosinophilia induced in C57BL/6 mice after Cryptococcus neoformans infection is driven by CD4(+) Th2 cells. The immunological mechanisms that protect against eosinophilia are not fully understood. Interaction of OX40 (CD134) and its ligand, OX40L, has been implicated in T cell activation and cell migration. Unlike CD28, OX40 is only expressed on T cells 1-2 days after Ag activation. Manipulation of this pathway would therefore target recently activated T cells, leaving the naive repertoire unaffected. In this study, we show that engagement of OX40 by an OX40L:Ig fusion protein drives IFN-gamma production by CD4(+) T cells and reduces eosinophilia and C. neoformans burden in the lung. Using gene-depleted mice, we show that reduction of eosinophilia and pathogen burden requires IL-12 and/or IFN-gamma. C. neoformans infection itself only partially induces OX40L expression by APCs. Provision of exogenous OX40L reveals a critical role of this pathway in the prevention of C. neoformans-induced eosinophilia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/OX40Ig,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6125-32
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12794142-Adjuvants, Immunologic,
pubmed-meshheading:12794142-Animals,
pubmed-meshheading:12794142-Antigens, CD27,
pubmed-meshheading:12794142-Antigens, Differentiation,
pubmed-meshheading:12794142-Bronchi,
pubmed-meshheading:12794142-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12794142-Cryptococcus neoformans,
pubmed-meshheading:12794142-Down-Regulation,
pubmed-meshheading:12794142-Eosinophils,
pubmed-meshheading:12794142-Female,
pubmed-meshheading:12794142-Injections, Intraperitoneal,
pubmed-meshheading:12794142-Interferon-gamma,
pubmed-meshheading:12794142-Ligands,
pubmed-meshheading:12794142-Lung,
pubmed-meshheading:12794142-Lymphocyte Activation,
pubmed-meshheading:12794142-Membrane Glycoproteins,
pubmed-meshheading:12794142-Mice,
pubmed-meshheading:12794142-Mice, Inbred C57BL,
pubmed-meshheading:12794142-Mice, Knockout,
pubmed-meshheading:12794142-Pulmonary Eosinophilia,
pubmed-meshheading:12794142-Receptors, OX40,
pubmed-meshheading:12794142-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12794142-Recombinant Fusion Proteins,
pubmed-meshheading:12794142-T-Lymphocyte Subsets,
pubmed-meshheading:12794142-Tumor Necrosis Factors
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pubmed:year |
2003
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pubmed:articleTitle |
OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia.
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pubmed:affiliation |
Center for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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