| pubmed-article:12794123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C0042749 | lld:lifeskim |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12794123 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12794123 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12794123 | pubmed:dateCreated | 2003-6-9 | lld:pubmed |
| pubmed-article:12794123 | pubmed:abstractText | HIV infection leads to numerous immunologic defects, including impaired B cell function. An effective humoral response requires bidirectional interactions between B cells and CD4(+) T cells, critical of which are interactions between CD80/CD86 expressed on activated B cells and CD28 expressed on responder CD4(+) T cells. In the present study, we examined the effect of active HIV replication on B cell costimulatory function. Induction of CD80/CD86 on B cells following B cell receptor and CD40 triggering and responsiveness of CD4(+) T cells to activated B cells were investigated in a system where B cells of HIV-infected patients were compared concurrently to B cells of HIV-negative donors. In contrast to HIV-aviremic patients, B cells of HIV-viremic patients were ineffective at stimulating CD4(+) T cells, as measured by the induction of activation markers and proliferation. The importance of interactions of CD80/CD86 and CD28 in activating CD4(+) T cells was clear; the ablation of a normal response following the addition of neutralizing anti-CD86/CD80 Abs mirrored the response of CD4(+) T cells to B cells of HIV-viremic patients, while the addition of exogenous CD28 ligands partially restored the poor CD4(+) T cell response to the B cells of HIV-viremic patients. Ineffective B cell costimulatory function in HIV-viremic patients was associated with low induction of CD80/CD86 expression on B cells. Our findings further delineate the scope of defects associated with cognate B cell-CD4(+) T cell interactions in HIV infection and suggest that therapeutic interventions designed to enhance CD28-dependent costimulatory pathways may help restore immune functions. | lld:pubmed |
| pubmed-article:12794123 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12794123 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12794123 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12794123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12794123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12794123 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12794123 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:ChunTae-WookT... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:HallahanClair... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:FauciAnthony... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:LiuShuyingS | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:EhlerLinda... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:MalaspinaAnge... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:MoirSusanS | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:PlantaMarie... | lld:pubmed |
| pubmed-article:12794123 | pubmed:author | pubmed-author:KottililShyam... | lld:pubmed |
| pubmed-article:12794123 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12794123 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12794123 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:12794123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12794123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12794123 | pubmed:pagination | 5965-72 | lld:pubmed |
| pubmed-article:12794123 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:12794123 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12794123 | pubmed:articleTitle | Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function. | lld:pubmed |
| pubmed-article:12794123 | pubmed:affiliation | Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:12794123 | pubmed:publicationType | Journal Article | lld:pubmed |
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